Olive leaf extract ole has been demonstrated to have antioxidant and antiinflammatory. Cimetidine appears to have protective effect on gentamicinlosartaninduced nephrotoxicity in rats. Calcium dobesilate is an antioxidant drug and this study is aimed to investigate the effects of calcium dobesilate on gentamicin induced nephrotoxicity. We performed a retrospective observational study to examine this and the predictive value of rifle stage on patient outcome in this setting. Diagnosis and treatment aminoglycoside nephrotoxicity typically is associated with nonoliguric acute renal failure, that is, azotemia in the presence. In this study, we aimed to investigate the possible protective effect of resveratrol on gentamicin induced nephrotoxicity. Rats were treated with curcumin 100 mgkg body mass by intragastric administration, once daily, followed with an intraperitoneal injection of gentamicin sulfate solution at a dose of 80 mgkg body mass for 8 consecutive days. Protective effects of nigella sativa against gentamicin. In this study we investigated the role of free radicals in gentamicin. However, gentamicin administration is limited because of nephrotoxicity.
Zeynab mohamadi yarijani, houshang najafi, and seyed hamid madani. The role of sex hormones in gonadectomized male and female rats fatemeheshraghijazi, 1 ardeshirtalebi, 1,2 fatemehsadatmirsaeedi, 1 sarinaahmadian, 1 fatemehmoslemi, 1 andmehdinematbakhsh 1,3,4 water and electrolytes research center, isfahan university of medical sciences, isfahan, iran. The expression patterns of nuclear factor erythroidderived 2like 2 nrf2, nuclear factor. The effects of sex hormones on gm induced nephrotoxicity in gonadectomized rats were investigated. Introduction gentamicin is an aminoglycoside antibiotic widely used for the treatment of bacterial infections. Gentamicininduced nephrotoxicity is a model of acute renal failure caused by oxidative stress generated through the induction of superoxide anions.
Assessment of gentamicininduced nephrotoxicity in rats. Aug 08, 2016 the aim of the current study was to investigate the mechanisms of renoprotection elicited by pinocembrin in gentamicin induced nephrotoxicity. Twenty four wistaralbino rats were divided into four equal groups as follows. Pdf calcium dobesilate for prevention of gentamicininduced. The present study was designed to determine the protective effect of salicylic acid sa in gentamicin induced nephrotoxicity in rats. Pinocembrin attenuates gentamicininduced nephrotoxicity. One of the complications of gentamicin and streptomycin is nephrotoxicity. The aim of the current study was to investigate the mechanisms of renoprotection elicited by pinocembrin in gentamicin induced nephrotoxicity. Gentamicin, cimetidine, losartan, vitamin e, rats, nephrotoxicity.
Ethanolic extract of garlic for attenuation of gentamicininduced nephrotoxicity in wistar rats hamid nasri,1 mehdi nematbakhsh,1 mahmoud rafieiankopaei2 introduction. The aim of the current study was to investigate the mechanisms of renoprotection elicited by pinocembrin in gentamicininduced nephrotoxicity. Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats. We studied gentamicin susceptibility of kidneys infected with e. Gentamicin induced nephrotoxicity is a model of acute renal failure caused by oxidative stress generated through the induction of superoxide anions. Ethanolic extract of garlic for attenuation of gentamicin. Comparative study on gentamicin and streptomycin induced nephrotoxicity in rats world small animal veterinary association world congress proceedings, 2004. Boron, a trace mineral, alleviates gentamicininduced. The present study was designed to determine whether flavocoxid has a protective effect against gentamicin induced nephrotoxicity in rats. Gentamicininduced acute renal failure model creative. Gentamicin nephrotoxicity is a common clinical situation in patients who receive it for a longer time period.
Osbeck against kidney histology of white wistar rats induced by gentamicin. The objective of the present study is to assess the effect of same s adenosyl methionine a precursor of glutathione endogenous antioxidant in gentamicin induced nephrotoxicity in rats, by measuring serum urea. Taken together, pharmacological interventions like antioxidants, ros scavengers and antioxidant enzymes are able to prevent gentamicininduced nephrotoxicity. Oleuropein is a natural antioxidant and scavenging free radicals. Attenuation of gentamicininduced nephrotoxicity in rats by. Inhibitory effect of olive leaf extract on gentamicininduced nephrotoxicity in rats majid tavafi, 1 hasan ahmadvand, 2 pooran toolabi 3 introduction. A single dose of gentamicin 30 mgkg, iv was given to different groups of rats alone, at the same time as, or on day 4, 7, 15, or 29 following cisplatin administration 6 mgkg, iv. To investigate the effect of probucol on gentamicin induced nephrotoxicity in rats. Pdf in this study, we aimed to investigate the possible protective effect of resveratrol on gentamicin induced nephrotoxicity. Gentamicin is a widely used antibiotic against serious and lifethreatening infections. Nephrotoxicity was induced in wistar rats by intraperitoneal administration of gentamicin 100 mgkgd for eight days. Effect of morin against gentamicininduced nephrotoxicity in.
Protective effect of crocin on gentamicininduced nephrotoxicity in rats. Salicylic acid attenuates gentamicininduced nephrotoxicity. The study findings indicate robust difference of the time course in rats of both treatment groups of gentamicin induced ototoxicity and nephrotoxicity, supporting the hypothesis these organ toxicities are independent of one another, and further suggest the observed treatmenttime differences in gentamicin adverse effects may be more dependent. Effects of bss on gentamicin nephrotoxicity in rats gentamicin administration caused kidney injury in rats, as indicated by significant increases in blood urea nitrogen bun and blood creatinine levels by 3 and 2fold, respectively, when compared with the non gentamicin control figure 3. In conclusion, b has a preventive effect against gentamicininduced nephrotoxicity and ameliorates kidney tissues of the rat. Increased nephrotoxicity of gentamicin in pyelonephritic rats. Pdf gentamicin induced nephrotoxicity in albino mice. Protective effect of pongamia pinnata flowers against. Gentamicininduced nephrotoxicity in rats ameliorated and. Effects of bss on gentamicin nephrotoxicity in rats gentamicin administration caused kidney injury in rats, as indicated by significant increases in blood urea nitrogen bun and blood creatinine levels by 3 and 2fold, respectively, when compared with the nongentamicin control figure 3. Protective effects of curcumin on acute gentamicininduced. Gentamicin was observed to cause a severe nephrotoxicity which was evidenced by an elevation of bun and creatinine levels.
A number of crude herbal extracts have been reported to ameliorate gentamicin induced nephrotoxicity. Research article sildenafil ameliorates gentamicin induced nephrotoxicity in rats. Attenuation of gentamicininduced nephrotoxicity in rats. Inhibitory effect of olive leaf extract on gentamicin. Most of the studies available in veterinary medicine in which nephrotoxicity of aminoglycosides has been studied are based on experimental models of acute renal injury caused by the administration of high doses of gentamicin. The defensive effects of hesperidin hdn, a bioflavonoid was investigated on gentamicin gen provoked nephrotoxicity in rats. Influence of spironolactone treatment on gentamicin. Protective effect of apocynin against the authors 2017. Research article gentamicin induced nephrotoxicity. Experiments were carried out in male wistar rats weighing 200250 g. Research article sildenafil ameliorates gentamicininduced nephrotoxicity in rats. Administration of nigella sativa extract prevented gentamicininduced nephrotoxicity in rats by reducing renal oxidative stress and enhancing antioxidant defense mechanism. Inhibitory effect of olive leaf extract on gentamicininduced.
Further, kidney damage induced by pathological events can be induced by extrinsic events such as hypertension. Effect of silymarin on gentamicin induced nephrotoxicty in albino rats. The role of sex hormones in gonadectomized male and female rats fatemeheshraghijazi, 1 ardeshirtalebi, 1,2 fatemehsadatmirsaeedi, 1 sarinaahmadian, 1. The effects of two nonsteroidal antiinflammatory drugs, ibuprofen 20 mg day. Effect of dimethyl sulfoxide on gentamicininduced nephrotoxicity in rats. For this purpose, we quantitatively evaluated gentamicininduced renal structural and functional. This study aimed to investigate the possible protective effect of apocynin apo on nephrotoxicity induced by gnt in rats. The effects of cisplatininduced nephrotoxicity on the pharmacokinetics of a renally excreted antibiotic, gentamicin, were studied in f344 rats. Protective effect of apocynin against gentamicininduced nephrotoxicity in rats show all authors. Finally, gentamicin nephrotoxicity is potentiated by magnesium depletion 27. Several parameters of renal function, histological changes on light and electron microscopy, and drug levels in renal parenchyma were com. The significant decrease in gsh and increases in mda levels, po and mpo activity indicated that gen. Animals were injected during 4 or 10 days with saline nacl. Effect of cyclooxygenase inhibitors on gentamicininduced nephrotoxicity in rats.
Boron, a trace mineral, alleviates gentamicininduced nephrotoxicity in rats springerlink. Dosedependent amelioration of gentamicininduced nephrotoxicity in adult swiss albino rats by vitamin bcomplex a preliminary study shaibu o bello 1,2 and aminu chika 1 1department of pharmacology, college of health sciences, usmanu danfodiyo university, 2fertility unit, karaye hospital, emir yahaya road, sokoto, nigeria. The aim of this study was focused on investigating the possible protective effect of ns against gsinduced nephrotoxicity. Gentamicininduced aki was established in female spraguedawley rats. Gentamicin sulphate nephrotoxicity seems to be attributed to the generation of reactive oxygen species. Materials and methods drugs and chemicals gentamicin and methylprednisolone were obtained. Pdf protective effect of crocin on gentamicininduced. Effect of morin against gentamicininduced nephrotoxicity. Oranges contain secondary metabolites such as flavonoids. Protective effect of bauhinia purpurea on gentamicin induced.
Gentamicininduced ototoxicity and nephrotoxicity vary. Borade department of pharmacology, rajgad dnyanpeeths college of pharmacy, bhor, m. The present results indicate that spironolactone aggravates gentamicin. Effect of morin against gentamicin induced nephrotoxicity in young male rats hala a. Flavocoxid attenuates gentamicininduced nephrotoxicity in. Aug 15, 2015 gentamicin is a widely used antibiotic against serious and lifethreatening infections.
Although a clear recognition of the patient and treatmentrelated risk factors, combined with the onceaday schedule and effective monitoring procedures, have definitely improved the situation over what prevailed in the early 1980s, we are still short of having brought the safety of. Protective effect of apocynin against gentamicininduced. Effects of cisplatininduced nephrotoxicity on gentamicin. Aug 24, 2019 nonetheless, b administration reversed gentamicin induced lipid peroxidation, antioxidant status, and inflammation. The effect of fleroxacin on gentamicininduced nephrotoxicity was evaluated with female spraguedawley rats. Pioglitazone attenuates kidney injury in an experimental. However, due to its side effects, there are some limitations in the use of gentamicin and streptomycin. Ameliorative effects of gallic acid on gentamicin induced nephrotoxicity in rats. The present study was designed to determine the protective effect of salicylic acid sa in gentamicininduced nephrotoxicity in rats. Inhibitory effect of olive leaf extract on gentamicin induced nephrotoxicity in rats majid tavafi, 1 hasan ahmadvand, 2 pooran toolabi 3 introduction. Calcium dobesilate is an antioxidant drug and this study is aimed to investigate the effects of calcium dobesilate on gentamicininduced nephrotoxicity. The effects of cisplatin induced nephrotoxicity on the pharmacokinetics of a renally excreted antibiotic, gentamicin, were studied in f344 rats. Ameliorative effect of berberine against gentamicininduced.
The aim of the present study was to evaluate the protective effect of crocin against gentamicininduced nephrotoxicity in rats. Comparative study on gentamicin and streptomycin induced. The present study was designed to determine whether flavocoxid has a protective effect against gentamicininduced nephrotoxicity in rats. Gentamicin gm is a widely used antibiotic against serious and lifethreatening infections, but its usefulness is limited by the development of nephrotoxicity. Effects of cosupplementation of vitamins e and c on. Gentamicin induces renal morphopathology in wistar rats scielo. Morin, a bioflavonoid with antioxidant properties, is a constituent of many herbs and fruits that are used as herbal medicines. Gentamicin, at doses of 50 or 100 mgkg body wt administered daily to healthy male mf1 mice by i. Aminoglycosides have long been one of the commonest causes of drug induced nephrotoxicity. Calcium dobesilate for prevention of gentamicininduced. A large body of in vitro and in vivo evidence indicates that reactive oxygen metabolites or free radicals are important mediators of gentamicin nephrotoxicity.
Multiple factors may increase the nephrotoxic potential of aminoglycosides. Pdf gentamicininduced nephrotoxicity in rats ameliorated and. Materials and methods drugs and chemicals gentamicin and. For this purpose, we quantitatively evaluated gentamicin induced renal structural and functional. Hence, this study was designed to evaluate the antioxidative, antiapoptotic, and antiinflammatory potential of the berberine against gminduced nephrotoxicity in rats. Calcium dobesilate for prevention of gentamicininduced nephrotoxicity in rats mostafa jafarey,1 saeed changizi ashtiyani,2 houshang najafi3 introduction.
Pdf calcium dobesilate for prevention of gentamicin. Research article sildenafil ameliorates gentamicininduced. All rats were killed at the end of the experiment, and then the blood, urine, and kidneys samples were taken. Experiments were carried out in male wistar rats weighing 200250g. The effect of fleroxacin on gentamicin induced nephrotoxicity was evaluated with female spraguedawley rats. Rats subjected to gentamicin induced nephrotoxicity, treated with pioglitazone at dose of 0. Protective role of hydroalcoholic extract of ficus carica. Pdf hesperidin protects gentamicininduced nephrotoxicity.
Ultimately, we reached the conclusion that the extent of nephrotoxicity of gentamicin was more and its recovery was less than streptomycin. India abstract gentamicin gminduced nephrotoxicity limits its longterm clinical use. Aminoglycoside nephrotoxicity kidney international. In conclusion, b has a preventive effect against gentamicin induced nephrotoxicity and ameliorates kidney tissues of the rat. Nephrotoxicity was induced in rats by intraperitoneal injection i. The aim of the present study was to evaluate the protective effect of crocin against gentamicin induced nephrotoxicity in rats. The incidence of gentamicin associated acute kidney injury aki as defined by the rifle criteria is unknown. Gentamicin and streptomycin are the most common antibiotics in group of aminoglycosides. Urinary metabolomic markers of aminoglycoside nephrotoxicity in newborn rats. Effect of cimetidine on gentamicinlosartan induced. Effect of morin against gentamicininduced nephrotoxicity in young male rats hala a. Cimetidine appears to have protective effect on gentamicin losartan induced nephrotoxicity in rats. Pioglitazone attenuates kidney injury in an experimental model of.
Influence of iron, deferoxamine and ascorbic acid on gentamicininduced nephrotoxicity in rats. Specifically, gentamicininduced nephrotoxicity model is mostly used to evaluate in vivo nephroprotective activity of natural compounds. Biochemical effects of oleuropein in gentamicininduced. In the present study, we examined effect of oleuropein on the paraoxonase 1 pon1 activity, lipid peroxidation, lipid profile, atherogenic indexes, and relationship of pon1 activity by highdensity lipoproteincholesterol hdlc and atherogenic indices in gentamicin gm induced nephrotoxicity in rats. Nephrotoxicity is a serious side effect of gentamicin and is believed to be related to reactive oxygen species in the kidney.
Aminoglycosideinduced nephrotoxicity is characterized by tubular necrosis. Pinocembrin attenuates gentamicininduced nephrotoxicity in. Protective effect of pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats annie shirwaikarl, s malini2, s chandrika kumari i i department of pharmacognosy, college of pharm. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicin administered rats. Gentamicin gm induced nephrotoxicity may be sex hormones related. Flavocoxid attenuates gentamicininduced nephrotoxicity in rats. Nephrotoxicity induced by gentamicin is a complex situation characterized by an increase in blood urea nitrogen bun and serum creatinine concentration, and tubular necrosis. Ameliorative effects of gallic acid on gentamicininduced. The damage to the kidney does not have to be induced by chemicals, thereby distinguishing renal pathology from nephrotoxicity.